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Training Course on Cancer Biology

The course is designed to provide post graduate and medical students with the education and training they need to make significant contributions to the field of cancer biology.

The coursework equips students with a broad understanding of the molecular, genetic, cellular biological and pathobiological aspects of cancer.

  1. Course Duration: 3 months
  2. Fees: 65K plus 18% GST (including accommodation)
  3. Faculty: Scientists and specialists from the fields of immunology, cancer biology, cell biology and stem cell biology.
  4. Batch details:

     A. Batch I: 1st December 2019

         Last date of registration: 20th September 2019

     B. Batch II: 1st June 2020

         Last date of registration: 20th March 2020

  1. Course intake: 20 Students per Batch
  2. Eligibility:
    • Sc. from Any Life Science Stream
    • PhD from Any Life Science Stream
    • Graduate and Postgraduate Medical Students

Note: A certificate will be awarded to the student upon completion of the course after a presentation and viva in front of the teaching faculty.

Theory

  1. Introduction to Cancer Biology
  • What is carcinogenesis? Theories behind the cause of cancer, Initiation, Promotion and Progression of Cancer.
  • Cancer and carcinogens: Role of DNA damage, repair and mutations, viruses and carcinogens.
  • Benign and Malignant tumours, Tissue specificity, Hyperplasia and Precancerous legions.

  1. Genetic, Molecular and Cellular Mechanisms of Cancer
  • Genome stability, Transcriptional controls in cancer, Suppression and activation of oncogenes during the transformation of a cell, Viral oncogenes, examples ERB, HER-2, rel, large T-antigen etc.
  • Cell cycle regulation and its alteration in cancer, Apoptosis, Necrosis, signalling pathways in cancer involving p53, Ras and Rb, Growth factors.

  1. Tumour Environment and Cell Interactions
  • Tumour cell dormancy in a microenvironment, Cell-Cell interactions, Cell matrix interactions, Invasive characters, the activity of Morphogens, Angiogenesis, Tumour Stem Cells.

  1. Types of Cancer
  • Leukaemia: types of chromosomal translocations.
  • Hodgkin’s lymphoma, Burkitt’s Lymphoma, HPV+ uterus cancer, Prostate cancer.

  1. Immunology and Tumours
  • Immune responses in tumour growth, Immune suppression by tumours, Tumour specific antigens and Immune response, immunotherapy by immune modulations.
  • Cancer Vaccines- Whole cell vaccines, Peptide vaccines, Dendritic vaccines, Prophylaxis.

  1. Cancer Research
  • Tumour specific Biomarkers for efficient diagnosis and prognosis
  • Imaging-Use of different Imaging Modalities for assessing molecular and functional aspects of Tumour cells.
  • DNA Microarrays- for an individual specific analysis of target tumour, example-lymphochip
  • Metastasis detection- Techniques and Challenges
  • Nanotechnology in tumour therapy- Nano vectors for targeted drug delivery
  • Bioinformatics- Early diagnosis, Personalized therapy by comparing patient’s tumour genetic profile to data of genetic profiles, respective treatments and responses globally
  • Treatment of cancer symptoms at molecular level targeting specific molecules, drug discovery.
  • Extensive clinical research of proposed treatment strategies for ensuring safety, efficacy and early implementation.
  • miRNAs- role in tumours and use in therapy

  1. Animal models in Cancer Biology
  • Introduction to animal studies/preclinical studies, the use of animals in cancer research. Design and execution of safety and efficacy parameters in cancer studies, Designing in Vivo protocol for cancer study, parameters to be studied during cancer induction/progression/treatment. (SGR, tumour doubling time, mortality analysis)

  • Analysis of the cell cycle of cancer cells
  • Analysis of apoptosis in cancer cell
  • Analysis of cell proliferation of cancer cells
  • Analysis of cancer cell surface markers
  • Analysis of cancer stem cells by flow cytometry (Aldefluor and surface markers)
  • Culture and analysis of different normal as well as cancer cell lines for various purposes from Mice and humans.
  • Bleeding techniques/organ collection
  • Cell-line induced carcinogenesis
  • Experimentation on epithelial-mesenchymal transition (EMT)